| Customization: | Available |
|---|---|
| Varieties: | Parasite Disease Prevention Medicine |
| Component: | Chemical Synthetic Drugs |
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| Active Ingredients | Content | |
| Maduramycin | Each 100g contains maduramysin 0.75g | |
| Nicarbazin | Each 100g contains Nicarbazine 8g | |
| Excipients | add to 100g |
Maduramycin 0.75%+Nicarbazin 8% Premix
Composition: Maduramycin Ammonium 0,75 gr., Nicarbazin 8 gr., excipients qs 100 gr.
PHARMACOLOGICAL PROPERTIES
It is a combination drug, which contains maduramicin and nicarbazin. Combination of active substances provides anti-Eimeria effect.
Maduramycin is eimeriostatic of wide range, effective against Eimeria Eimeria tenella, E.acervulina, E.necatrix, E.maxima, E.mivati, E. brunetti etc. Maduramicin belongs to group of polyether monocarboxylic ionophoric antibiotics, produced from a strain of Actinomadura Yumanensis.
The mechanism of drug action is based on the selective increase of transport of monovalent cations (sodium and potassium ions) through the cell membrane of Eimeria disrupting cell turgor with following swelling of cytoplasm further destruction of Eimeria through destruction of the cell membrane. Maduramicin ammonium is practically not absorbed in gastrointestinal tract, showing its action on the mucous and submucous membranes. Excreted from the body of poultry unchanged, mainly with feces within 2-3 days.
Nicarbazin is synthetic anticoccidial drug, which is a complex of 4,4'-dinitro-diphenyl-urea (DNC) and 2-hydro-4,6-dimethyl-pyrimidin (HDP), which inhibits energy metabolism in the body of parasite.
Maduramycin and nicarbazin have wide range anticoccidial effect on Eimeria of poultry (Eimeria tenella, E. acervulina, E. necatrix, E. maxima, E. mivati, E. brunettі). Nicarbazin is synthetic complex of 4,4'-dinitro-carbanilide (DNC) and 2-hydroxy-4,6-dimethyl-pyrimidin (HDP). Dinitro-carbanilide (DNC) has anticoccidial effect against Eimeria and not hydroxy-dimethyl-pyrimidin (HDP). DNC-HDP complex in gastrointestinal tract leads to formation of DNC crystals much smaller in size than one water-insoluble DNC, which explains the above efficiency of the complex. Nicarbazin in lower sections of gastrointestinal tract decomposes to DNC and HDP, which then can be absorbed independently.
Simultaneous action of maduramycin and nicarbazin prevents the drug resistance development of Eimeria.
The drug is practically not absorbed in gastrointestinal tract of poultry and acts upon Eimeria in mucous membrane of gastrointestinal tract, excreted from the body with feces; by rate of action on the body belongs to low toxicity substances (toxicity category IV).
Maduramycin 0.75%+Nicarbazin 8% belongs to low toxicity drugs and in recommended amounts doesn't show local irritation, toxic-resorptive or sensitizing actions. The drug is toxic to horses.
Compatible with vitamins and feed additives used in poultry.
APPLICATION
Preventive treatment and treatment of eimeriosis in chicken (broiler chickens and rearing stock of chickens).
Therapeutic indications: For the prevention of coccidiosis in broiler chickens caused by Eimeria Acervulina, E. Necatrix, E. Brunetti, E. Máxima, E. Mitís, E. Tenella.
Dosage and administration: 500 gr. of premix Plus in a ton of food.
It has to be administered to poultry from their birth until 5 days prior to their slaughter.
Commercial presentation: 25 kg bags.
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